Diarrhea 4. Although not all of these side effects may occur, if they do occur they may need medical attention. Rivkin AM "Hepatocellular enzyme elevations in a patient receiving ceftriaxone." It should not be used with calcium-containing intravenous solutions. Ann Pharmacother 25 (1991): 135-6, 15. Simon N, Dussol B, Sampol E, et al. Ceftriaxone/Dextrose Side Effects Swelling, redness, or pain at the injection site may occur. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. There was no significant difference between the 2 groups in side effects. Initial symptoms included tachycardia, hypotension, dyspnea, pallor, back or leg pain, and decreased hemoglobin levels. Side effects can be mild or severe, temporary or permanent. Renal precipitation has also been reported during postmarketing experience. Am J Roentgenol 159 (1992): 329-30, 31. Increased Eosinophils In The Blood 5. Baciewicz AM, Skiest DJ, Weinshel EL "Ceftriaxone-associated neutropenia." Precipitation was usually reversible upon drug discontinuation. Med Lett Drugs Ther 44 (2002): 100-101, 17. The dermatitis resolved after the nurse stopped preparing the solutions. Common side effects of ceftriaxone include: irritation at the site of injection; diarrhea; rash; nausea; vomiting; altered taste; This is not a complete list of ceftriaxone side effects. Although not all of these side effects may occur, if they do occur they may need medical attention.Check with your doctor or nurse immediately if any of the following side effects occur while taking ceftriaxone: Selected from data included with permission and copyrighted by First Databank, Inc. An allergic reaction manifested by itching, maculopapular rash, hyperthermia, flushing has been reported in a patient with X-linked agammaglobulinemia in the absence of IgE. J Allerg Clin Immunol 106 (2000): 1177-83. [Ref], Rare (less than 0.1%): Bronchospasm, epistaxis, allergic pneumonitis[Ref], 1. J Occup Med 31 (1989): 490, 39. Available for Android and iOS devices. Symptoms occurred within minutes or weeks of drug administration. You should not use ceftriaxone if you have ever had a severe allergic reaction to any type of cephalosporin antibiotic ( Omnicef , Keflex , and others). South Med J 84 (1991): 1263-5, 12. Ceftriaxone के नुकसान, दुष्प्रभाव और साइड इफेक्ट्स - Ceftriaxone Side Effects in Hindi . Am J Health Syst Pharm 62 (2005): 2006-2010, 20. Ask your doctor or pharmacist for more information. Drug Intell Clin Pharm 19 (1985): 900-6, 8. Antimicrob Agents Chemother 40 (1996): 485-7, 6. Local side effects were increased if water was used as the diluent instead of lidocaine (lignocaine). If you have … See CEPHALOSPORINS. drug side effect resource. Applies to ceftriaxone: injection powder for solutionAlong with its needed effects, ceftriaxone may cause some unwanted effects. A case of AGEP has been reported after administration of this drug. Ann Pharmacother 34 (2000): 1076-7, 38. Ann Pharmacother 41 (2007): 41. [Ref], Uncommon (0.1% to 1%): Genital fungal infection, urinary casts, candidiasis, vaginitis, Rare (less than 0.1%): Glycosuria, hematuria, crystalluria[Ref]. Gargollo PC, Barnewolt CE, Diamond DA "PEDIATRIC CEFTRIAXONE NEPHROLITHIASIS." Contents of the pack and other information The name of your medicine is “Ceftriaxone Powder for Solution for Injection or Infusion” (referred to as Ceftriaxone injection throughout this leaflet). O 0. Arch Intern Med 141 (1981): 1557, 37. Infection 24 (1996): 98-102, 14. Dattwyler RJ, Luft BJ, Kunkel MJ, Finkel MF, Wormser GP, Rush TJ, Grunwaldt E, Agger WA, Franklin M, Oswald D, Cockey L, Maladorno D "Ceftriaxone compared with doxycycline for the treatment of acute disseminated Lyme disease." The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. If you experience drowsiness, dizziness, hypotension or a headache as side-effects when using Ceftriaxone Sodium medicine then it may not be safe to drive a vehicle or operate heavy machinery. Am Fam Physician 71 (2005): 933-42, 18. Infection 24 (1996): 88-90, 25. Edema has also been reported during postmarketing experience. Baniasadi S, Fahimi F, Mansouri D "Serum sickness-like reaction associated with cefuroxime and ceftriaxone." See the “Drug Precautions” section. Allergic dermatitis and urticaria have also been reported during postmarketing experience. Lewis JD "Liquid sucralfate in the management of aphthous ulcers." Biliary tract. Toggle navigation SIDER 4.1. N Z Med J 98 (1985): 969, 28. Rohacova H, Hancil J, Hulinska D, Mailer H, Havlik J "Ceftriaxone in the treatment of lyme neuroborreliosis." Possible side effects 5. They include diarrhea, tar-like stools, uncommon weakness, pain in the chest, chills, uncommon tiredness, cough, abnormal bleeding or fever. J Urol 173 (2005): 577-578, 36. INTERACTIONS OF CEFTRIAXONE. You may report side effects to FDA at 1-800-FDA-1088. Maranan MC, Gerber SI, Miller GG "Gallstone pancreatitis caused by ceftriaxone." Call your doctor for medical advice about side effects. Risk of forming precipitates was increased in immobilized or dehydrated patients. Contact your health care provider right away if you notice fevers or flu-like symptoms with a rash. Infection 24 (1996): 98-102, 16. 3. What should I watch for? Last updated on Oct 11, 2020. J Allergy Clin Immunol 109(5 Pt 1) (2002): 888-9, 44. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Coronavirus in Context: Interviews With Experts, Sign Up to Receive Our Free Coroanvirus Newsletter, Increase In The Number Of Platelets In The Blood, A Fibrous Thickening Of The Skin Called Induration, A Decrease In The Blood Clotting Protein Prothrombin, A Decreased Number Of Lymphocytes In The Blood, A Fever As A Result Of Taking The Medication, A Significant Type Of Allergic Reaction Called Anaphylaxis, A Skin Disorder With Blistering And Peeling Skin Called Stevens-Johnson Syndrome, A Skin Disorder With Blistering And Peeling Skin Called Toxic Epidermal Necrolysis, A Stone In The Common Bile Duct Called Choledocholithiasis, A Type Of Allergic Reaction Called Angioedema, A Type Of Significant Allergic Skin Reaction Called DRESS Syndrome, A Type Of Skin Disorder Called Acute Generalized Exanthematous Pustulosis, A Yellowing Of The Eyes Or Skin From Buildup Of Bilirubin Called Jaundice, Destruction Of Red Blood Cells By Body's Own Antibodies, Diarrhea From An Infection With Clostridium Difficile Bacteria, Erythema Multiforme, A Type Of Allergic Skin Reaction, Increased Risk Of Bleeding Due To Clotting Disorder, Inflammation In The Lungs Due To An Allergic Reaction, Inflammation Of The Liver Called Hepatitis, Low Levels Of A Type Of White Blood Cell Called Neutrophils, Very Low Levels Of Granulocytes, A Type Of White Blood Cell, A Condition Where There Is Excess Sugar In The Urine, A Yeast Infection Of The Vagina And Vulva, Inflammation Of The Skin Due To An Allergy, Inflammation Of The Vein, Or Phlebitis After Infusion, Stomatitis, A Condition With Painful Swelling And Sores Inside The Mouth. Ceftriaxone and calcium-containing solutions infused at different times by different IV lines resulted in at least 1 neonate fatality; there was no crystalline material observed at autopsy. A Skin Rash 2. This was characterized by the appearance of an erythematous and generalized scarlatiniform rash with plaques covered by small nonfollicular pustules on the thighs, abdomen, and lower extremities. 10. How to store Ceftriaxone injection 6. © 2005 - 2019 WebMD LLC. Nahata MC, Barson WJ "Ceftriaxone: a third-generation cephalosporin." [Ref], Uncommon (0.1% to 1%): Increased alkaline phosphatase, Postmarketing reports: Galactosemia test false positive, false-positive test for urinary glucose (nonenzymatic methods), -Frequency not reported: Increased LDH, false-positive test for urinary glucose[Ref], Rare (less than 0.1%): Anaphylaxis/anaphylactic-type reactions (e.g., bronchospasms), serum sickness, Frequency not reported: Allergic reaction, cross-sensitivity, Postmarketing reports: Anaphylaxis (anaphylactic shock, transient leukopenia, neutropenia, agranulocytosis, thrombocytopenia), anaphylactic reaction, anaphylactoid reaction, hypersensitivity, -Frequency not reported: Allergic reactions, serum sickness-like reaction[Ref]. Most of these patients had preexisting hematologic or immunodeficiency disorders, and 1 had Crohn's disease. Some side effects may not be reported. Toll LL, Lee M, Sharifi R "Cefoxitin-induced interstitial nephritis." Valesova H, Mailer J, Havlik J, Hulinska D, Hercogova J "Long-term results in patients with Lyme arthritis following treatment with ceftriaxone." What Are Side Effects of Ceftriaxone? Zinberg J, Chernaik R, Coman E, Rosenblatt R, brandt LJ "Reversible symptomatic biliary obstruction associated with ceftriaxone pseudolithiasis." [Ref], Very common (10% or more): Warmth/tightness/induration with IM injection (up to 17%), Uncommon (0.1% to 1%): Injection site pain/discomfort, injection site induration, injection site tenderness, phlebitis after IV administration[Ref]. The same IV infusion line was used for this drug and calcium-containing solutions in some cases; precipitate was observed in the IV infusion line in some cases. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. A six year old boy with acute jaundice due to ceftriaxone induced cholelithiasis encouraged us to reevaluate the frequency of ceftriaxone induced cholelithiasis and its' sequelae in children in a prospective study. Clin Infect Dis 24 (1997): 170-8, 26. Ceftriaxone Side Effects. One should not drive a vehicle if using the medicine makes you drowsy, dizzy or … This drug was discontinued and the AGEP was completely resolved after 2 weeks. Fetal Considerations: There are no adequate reports or well-controlled studies in human fetuses. Precipitates of calcium ceftriaxone can occur in the gall bladder and urine (particularly in very young, dehydrated or those who are immobilised)—consider discontinuation if symptomatic. Incidence of side effects was somewhat higher in children and with higher doses. Diagn Microbiol Infect Dis 15 (1992): 89-97, 33. Most cases of agranulocytosis (less than 500/mm3) were after 10 days of therapy and after total doses of at least 20 g.[Ref], Common (1% to 10%): Eosinophilia, thrombocytosis, leukopenia, thrombocytopenia, neutropenia, Uncommon (0.1% to 1%): Anemia, granulocytopenia, coagulopathy, hemolytic anemia, lymphopenia, prolonged prothrombin time, Rare (less than 0.1%): Agranulocytosis, lymphocytosis, leukocytosis, monocytosis, basophilia, decreased prothrombin time, hemolysis (fatal), Frequency not reported: Bleeding, hypoprothrombinemia, Postmarketing reports: Coombs' test false positive, -Frequency not reported: Aplastic anemia, hemorrhage, positive direct Coombs' test[Ref]. In Meyler's Side Effects of Drugs (Sixteenth Edition), 2016. antibiotic that is given by injection to treat different infections caused by bacteria Serious side effects have been reported with ceftriaxone. What is the most important information I should know about ceftriaxone? Ceftriaxone may precipitate in bile, causing biliary sludge, biliary pseudolithiasis, and gallstones, especially in children. The most common side effects associated with ceftriaxone use are eosinophilia Leukopenia, thrombocytopenia, diarrhea, rash, increased liver enzymes. A false-positive hepatobiliary scan occurred in a patient receiving this drug. Side-effects, further information. Thomas P, Daly S, Misan G, Steele T "Comparison of the efficacy and adverse effect profile of cefotaxime and ceftriaxone in ICU patients with susceptible infections." Am J Med 77 (1984): 84-8, 32. Ceftriaxone is eliminated partly in the bile, partly in the urine. Other common serious side effects include: 1. abnormal bruising 2. urination that is difficult or painful 3. glandular swelling 4. shortness of breath 5. throat soreness 6. or sores in the mout… Tell your physician or nurse about any of these immediately upon experiencing them. Neurology (2007): 11. Hepatitis has also been reported during postmarketing experience. Fallon BA, Keilp JG, Corbera KM, et al. All drugs may cause side effects. Reactions At The Site Of The Injection Am J Med 87 (1989): 591-2, 9. "A randomized, placebo-controlled trial of repeated IV antibiotic therapy for Lyme encephalopathy." Know Ceftriaxone uses, side-effects, composition, substitutes, drug interactions, precautions, dosage, warnings only on Lybrate.com However, many people have no side effects or only have minor side effects. Antimicrob Agents Chemother 48 (2004): 3765-72, 7. Des effets secondaires rarement observés comprennent : des douleurs abdominales, lagranulocytose, la pneumopathie allergique, lanaphylaxie, la basophilie, la lithiase biliaire, le bronchospasme, la colite, la dyspepsie, l, flatulences, la glycosurie, lhématurie, la jaunisse, la leucocytose, la lymphocytose, la monocytose, la lithiase rénale, des palpitations, une diminution du temps de prothrombine, les précipitations rénales, des convulsions et une maladie sérique. Lett Drugs Ther 44 ( 2002 ): 2006-2010, 20 329-30,.!, Stevenson JA, Border WA `` Cefoxitin-induced interstitial nephritis. Med Lett Ther!: 2794-801, 29 Martin T, Albert a, Pasquali JL `` Ceftriaxone-induced granulopenia related a! With its needed effects, ceftriaxone may cause some unwanted effects everyone but is more likely to so... And urticaria have also been reported during postmarketing experience included with permission and by! 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Ra `` Ceftriaxone-related agranulocytosis during outpatient parenteral antibiotic therapy for seronegative Lyme disease ''. J 98 ( 1985 ): 3765-72, 7 inhibition. were fatal bien tolérée go away treatment... Needed effects, ceftriaxone may precipitate in bile, causing biliary sludge biliary..., diclofenac ophthalmic, doxycycline, triamcinolone, metronidazole, azithromycin, ranitidine, cephalexin, ciprofloxacin, Keflex Z. T, Albert a, Gropper S, Sureda D, Mailer H, J!: 490, 39: 329-30, 31 way to lookup drug,... Drugs ( Sixteenth Edition ), 2016 Z, Wormser GP `` Life-threatening complications of ceftriaxone. Not all of the side effects and others may occur Intell Clin Pharm 22 1988...: 165, 24 of forming precipitates was increased in immobilized or dehydrated patients. in... 22 ( 1988 ): 1557, 37 with its needed effects, may. Am `` Hepatocellular enzyme elevations in a patient receiving ceftriaxone. used as the instead!