The primary use of phthalic anhydride is a precursor to phthalate esters, used as plasticizers in vinyl chloride.Phthalate esters are derived from phthalic anhydride by the alcoholysis reaction. SCHEMBL1681510. Phthalic acid esters (PAEs), a class of organic pollutants with potent endocrine-disrupting properties, are widely present in municipal sludge. Synonym: 1,2-Benzenedicarboxylic acid 1-(phenylmethyl) ester, Phthalic acid monobenzyl ester Empirical Formula (Hill Notation): C 15 H 12 O 4 Molecular Weight: 256.25 May 2014; Medicinski Pregled 67(5-6):172-5; DOI: 10.2298/MPNS1406172B. These mammalian pancreatic CEases have been found to be nonspecific for degradation in relation to the diversity of the alkyl side chains of PAEs. Some of the PAEs are also used as the vehicle for perfumes. Phthalic Acid Ester. This paper provided the first data on the concentration, distribution, congener profile, sources and potential risk of phthalic acid eaters (PAEs) in soil of vegetable fields from the suburbs of Xianyang city, Northwest China. A wide variety of phthalic acid ester options are available to you, such as grade standard, usage, and type. Phthalic anhydride can also be prepared from phthalic acid by simple thermal dehydration. The efficiency of activated carbon suspended in aqueous medium for the adsorption of PA has been analyzed. 1-O-butyl 2-O-(4-methylpentyl) benzene-1,2-dicarboxylate Effects of phthalic acid esters on fetal health. Phthalic acid and phthalate esters are of growing interest due to their significant usage and potential toxicity. … However, their effect on antibody concentrations in children is still under investigation. Phthalates are diesters of 1,2-benzenedicarboxylic acid (phthalic acid) containing a benzene ring with two ester functional groups (Fig. Liao C(1), Yang P, Xie Z, Zhao Y, Cheng X, Zhang Y, Ren Z, Guo Z, Liao J. Phthalic acid is the final common metabolite of phthalic acid esters (PAEs). Science 06 Oct 1972: Vol. [Article in Chinese] Wang KR(1), Cui MM(2), Shi YX(2). Epub 2019 Oct 13. The dramatic increase in the production of synthetic fibers, processed foods, pesticides, plastics, pharmaceuticals, and a thousand other materials has completely altered our immediate human environment and provided a wealth of new materials. Consequently, phthalates are found in human residential and occupational environments in high concentrations, both in air and in dust. Soil samples were taken evenly from the top and bottom soil horizons using a zig-zag pattern. 46-47 DOI: 10.1126/science.178.4056.46 . Urban sprawl worldwide warrants the use of large quantities of industrial and household products containing phthalic acid esters (PAEs) resulting in adverse impacts on the quality of aquatic life in urban watercourses. Application of GC-triple quadrupole MS in the quantitative confirmation of polycyclic aromatic hydrocarbons and phthalic acid esters in soil. By Jean L. Marx. butyl isohexyl phthalate. Article; Info & Metrics; eLetters; PDF; This is a PDF-only article. Phthalic Acid Phthalate Ester Bioaccumulation Factor Phthalic Anhydride High Performance Liquid Chromatogra These keywords were added by machine and not by the authors. Phthalic acid esters (phthalates) are used as plasticizers in numerous consumer products, commodities, and building materials. Phthalates are also ubiquitous food and environmental contaminants. [Phthalic acid esters (PAEs) pollution in farmland soils: a review]. Author information: (1)Institute of Agriculture Ecological and Environmental Health, Qingdao Agricultural University, Qingdao 266109, Shandong, China. Phthalic acid esters (phthalates) are used as plasticizers in numerous consumer products, commodities, and building materials. Recent studies show that DEP, a phthalic acid ester (PAE), is enzymatically hydrolyzed to its monoesters by pancreatic cholesterol esterase (CEase) in pigs and cows. 2020 Jan 25;1611:460620. doi: 10.1016/j.chroma.2019.460620. This process is experimental and the keywords may be updated as the learning algorithm improves. Consequently, phthalates are found in human residential and occupational environments in high concentrations, both in air and in dust. Most of the phthal- ates are plasticizers; they can be in- corporated into resins, usually poly- vinyl chloride (PVC), to impart the Effects of Phthalic Acid Esters onthe Liver andThyroid* by Richard H. Hinton,t Fiona E. Mitchell,t Alan Mann,t DawnChescoe,tShirley C. Price,t Alistair Nunn,t Paul Grasso,t andJamesW. It has been reported that exposure to PAE affects the immune response. Phthalic Acid Esters: Biological Impact Uncertain. About 1% of these are Pharmaceutical Intermediates, 0% are Ester & Derivatives, and 0% are Other Chemicals. Synonym: 1,2-Benzenedicarboxylic acid 1,2-bis(1-methylethyl) ester, NSC 15315, Phthalic acid diisopropyl ester Empirical Formula (Hill Notation): C 14 H 18 O 4 Molecular Weight: 250.29 Its interaction with well-ordered MgO(100) (magnesium oxide) thin films has been investigated. China. Uses Phthalate esters plasticizers. Epub 2019 Oct 14. … Phthalic acid (PA) is the final metabolite of phthalic acid esters (PAEs). Phthalic acid has applications in the preparation of phthalate ester plasticizers[1]. Phthalic acid esters (PAEs) rank among the primary risk pollutants and their adverse effects may endanger the environmental balance and affect the ontogenetic development of live organisms and their body functions. Phthalic acid esters have been used as plasticizers in numerous products and classified as endocrine-disrupting compounds. title = "Phthalic Acid Esters", abstract = "The twentieth century can as properly be called the age of organic chemistry as it can the atomic age. Alibaba.com offers 943 phthalic acid ester products. 2020;55(2):148-154. doi: 10.1080/03601234.2019.1674103. Author information: (1)Sichuan Environmental Monitoring Centre, Chengdu, Sichuan, 610041, P.R. Phthalate esters are commonly used as plasticizers to impart flexibility to plastics, particularly polyvinylchloride polymers (PVCs), which have a wide variety of biomedical and other uses such as building and construction, home furnishings, cars, clothing, and food wrappings. 44.1) and they are synthetically produced by esterification of phthalic acid with different alcohols.Depending on the alcohols employed, molecules with different physicochemical properties are obtained. Phthalic acid, butyl isohexyl ester. Phthalic acid can be used for the synthesis of synthetic agents, such as isophthalic acid (IPA), and terephthalic acid (TPA). Compound Phthalic acid, dipropyl ester with free spectra: 3 NMR, 3 FTIR, and 3 MS. See all Hide authors and affiliations. Di-(2-ethylhexyl) phthalate was the major phthalic acid ester in the Mississippi River estuary, with mean levels of 0.1 μg/g (dry weight) in surface sediments, 1.0 μg/liter in river water, and 0.7 μg/liter in delta water. A recent food safety concern has arisen from the unapproved use of certain phthalates in a broad range of food/nutraceutical ingredients from Taiwan [53]. Polyethylene terephthalate (PET) and glass are both widely used materials for bottled drinking water. . Bacteria that grew aerobically on dibutyl phthalate and o-phthalic acid were readily detected in the sediments and water. Crossref Sergey V. Basenko, Anastasiya S. Soldatenko, Silacyclophanones – cyclic organosilicon esters of isophthalic acid, Chemistry of Heterocyclic Compounds, 10.1007/s10593-018-2239-5, 54 , 1, (100-102), (2018). Analysis of phthalic acid esters in sea water and sea sand using polymer-coated magnetic nanoparticles as extraction sorbent J Chromatogr A. Monitoring took place in twelve regions of the Czech Republic. Phthalates have been used in food contact materials and are generally allowed for this use. Diminution of migration of phthalic acid esters in tequila beverage by the year of production J Environ Sci Health B. Phthalic acid esters (PAEs) have long been known as the most widely used plasticizer with a broad range of industrial application. Phthalic acid esters (phthalates) have been used as industrial plasticizers in a wide range of consumer products. Bridgest Theeffects, overperiods from3 daysto9 monthsofadministration, ofdiets containingdi-2-ethylhexyl 178, Issue 4056, pp. Phthalic Acid Esters: Biological ImpactUncertain Phthalic acid esters-approximately 1 billion pounds in 1972-are widely used in industry, in the home, and in medical sciences. The aim of the study was monitoring of phthalic acid esters in agricultural soils of the Czech Republic over the period of 6 years, namely dibutyl phthalate (DBP) and di-2-ethylhexyl phthalate (DEHP). Phthalic acid esters (PAE) are widely used during chemical synthesis and do not form covalent linkages with products. As China is one of the largest consumers of phthalic acid esters, some human activities may lead to the accumulation of phthalic acid esters in soil and result in contamination. Chronic toxicity and carcinogenicity studies of several phthalic acid esters (PAEs) and compounds containing a 2-ethylhexyl moiety were conducted in Fischer 344 rats and B6C3F1 (hybrid) mice. Related Catalog Phthalic acid esters (PAEs) are the most commonly used plasticizers which are added to provide desired flexibility and clarity to the polyvinyl chloride (PVC) plastics used in packaging, storage and delivery of food, drugs and cosmetics. Phthalic acid diethyl ester 99%; EC Number: 201-550-6; find Sigma-Aldrich-P5787 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich. Source; PubMed; Authors: Ivana Bajkin. The average concentrations of ΣPAEs in water samples were 3.16 ± 2.16 μg L -1 in … The spatial and temporal distribution, congener profiles and ecological risk of phthalic acid esters (PAEs) were investigated in the seawater and sediment samples from the East China Sea in spring and autumn. PAEs are ubiquitous in different environments and our daily life due to their large and widespread application. Cyclic organosilicon esters of ortho-phthalic acids, Chemistry of Heterocyclic Compounds, 10.1007/s10593-019-02592-5, (2019). PAEs in all topsoil samples analyzed were detected, indicating that PAEs were ubiquitously environmental contaminants. Phthalates are also ubiquitous food an … We aimed to examine … Adsorption of PA has been analyzed ester options are available to you, such grade. Pharmaceutical Intermediates, 0 % are Other Chemicals Pregled 67 ( 5-6 ):172-5 ; DOI:.. 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